Using Mass Spectrometry for Drug Metabolism Studies

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Mass Spectrometry in Drug Metabolism

Figure 1 highlights the localization of CLZ in discrete organs of the whole-body more than 15 tissues. Figure 2 shows the corresponding mass spectrum obtain using CID fragmentation method, several daughter ions are observed in agreement with fragmentation pathway of CLZ. Moreover, the spectral resolution power of the instrument up to avoids potential interferences due to surrounding biological matrix.

Relative quantification of the drug can be then obtained, CLZ shows higher signal in liver, kidney and lung stomach excluded than in brain, its targeted tissue. Biotransformation products of CLZ have also been monitored.

Interestingly, metabolite distributions are quite different from the parent drug distribution. Thus, reliable and robust pharmacokinetics data can be obtained from a single MSI experiment to ensure the right targeting of the drug and of its metabolites within tissue section. Whole-body imaging using MSI gives access to a wide range of endogenous molecule classes specific to histological regions of the tissue.

Figure 3 listed several molecules of interest with their corresponding adduct form and mass accuracy measurement. We can observe on Figure 4 some preferential histological distributions of these molecules within tissue section which can be used to obtain a molecular histology of the sample.

Online electrochemistry/mass spectrometry in drug metabolism studies: principles and applications.

Heme b is a robust marker of blood mainly distributed in surrounded tissue and in the heart. Lipids such as PCs are well ionized in mass spectrometry and in MSI their distribution are often correlated with specific tissue type.

Pathways of Drug Metabolism - Module 3, Session 1

PCs are detected in spinal cord and in the brain with some differences concerning saturated one more concentrated in the cerebral cortex than is the spinal cord. Shuguang Ma, Swapan K. Chowdhury and Kevin B.


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Journal Name: Current Drug Metabolism. Volume 7 , Issue 5 , Journal Home. Close Print this page.


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